Metabolomic study of urinary polyamines in rat exposed to 915 MHz radiofrequency identification signal
- 주제(키워드) Gas chromatography-mass spectrometry , Metabolomic analysis , Radiofrequency identification , Star pattern recognition , Urinary polyamines
- 등재 SCIE, SCOPUS
- 발행기관 Springer-Verlag Wien
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000119230
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s00726-015-2079-x
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Metabolomic analysis of urinary polyamines (PAs) from rat exposed to 915 MHz radiofrequency identification (RFID) signal for 8 h/day for 2 weeks was performed by gas chromatography–mass spectrometry as N-ethoxycarbonyl/N-pentafluoropropionyl derivatives. Large alterations in nine PA levels including four aliphatic and five acetylated PAs were monitored in sham-exposed and RFID-exposed groups. Total PA and urinary levels of N1-acetylputrescine, N1-acetylcadaverine, putrescine, cadaverine, N1-acetylspermidine, N8-acetylspermidine, spermidine and spermine were reduced, whereas N1-acetylspermine was significantly increased after sham and RFID exposure compared with those before exposure. Their levels were normalized to the corresponding group means before exposure and then plotted into star symbol patterns. N1-Acetylspermine after RFID exposure was 54 % higher compared to the level before RFID exposure, while it was elevated by only 17 % in the sham group. The results suggest that 915 MHz RFID exposure may induce metabolic disturbance of PA. It may also elevate spermidine/spermine acetyltransferase (SSAT) activity. Thus, the present metabolic profiling combined with star pattern recognition method might be useful for understanding the complexity of biochemical events after exposure to RFID signal. © 2015 Springer-Verlag Wien
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