Dose-dependency of dexamethasone on the analgesic effect of interscalene block for arthroscopic shoulder surgery using ropivacaine 0.5% :A randomised controlled trial
- 등재 SCIE, SCOPUS
- 발행기관 Lippincott Williams and Wilkins
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000119600
- 본문언어 영어
- Published As http://dx.doi.org/10.1097/EJA.0000000000000213
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
BACKGROUND: Dexamethasone prolongs the duration of single-shot interscalene brachial plexus block (SISB). However, dose-dependency of dexamethasone as an adjuvant for SISB remains insufficiently understood. OBJECTIVE :The objective of this study is to evaluate the effect of different doses of dexamethasone on the duration of SISB using ropivacaine 0.5%. DESIGN :A randomised, double-blind controlled trial. SETTING :Single university tertiary care centre. PATIENTS: One hundred and forty-four patients scheduled for elective arthroscopic shoulder surgery were allocated randomly to one of four groups. INTERVENTIONS: Patients received 12 ml of ropivacaine 0.5% in 0.9% saline (control group), or containing dexamethasone 2.5, 5.0 or 7.5mg for SISB. MAIN OUTCOME MEASURES :The primary endpoint was the time to the first analgesic request. Pain scores and adverse effects were also assessed up to 48 h postoperatively. RESULTS: Inclusion of dexamethasone 2.5, 5.0 and 7.5mg resulted in significant (P<0.001) increases in time to the first analgesic request by factors of 1.6, 2.2 and 1.8, respectively. The percentages of patients not requiring analgesics in the first 48 h postoperatively with dexamethasone 0.0, 2.5, 5.0 and 7.5mg were 3, 22, 39 and 33%, respectively (P<0.001). There were no significant effects on pain scores or incidences of adverse effects. CONCLUSION: Dexamethasone demonstrated significant beneficial dose-dependent effects on duration to the first analgesic request, the number of patients not requiring analgesics and analgesic use in the first 48 h after SISB for arthroscopic shoulder surgery. There were no significant effects on pain scores or incidences of adverse effects. Copyright © 2015 European Society of Anaesthesiology. All rights reserved.
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