Rutin increases muscle mitochondrial biogenesis with AMPK activation in high-fat diet-induced obese rats
- 주제(키워드) AMPK activity , Mitochondria , Obesity , Rutin , Skeletal muscle
- 등재 SCIE, SCOPUS
- 발행기관 MDPI AG
- 발행년도 2015
- URI http://www.dcollection.net/handler/ewha/000000119715
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/nu7095385
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Decreased mitochondrial number and dysfunction in skeletal muscle are associated with obesity and the progression of obesity-associated metabolic disorders. The specific aim of the current study was to investigate the effects of rutin on mitochondrial biogenesis in skeletal muscle of high-fat diet-induced obese rats. Supplementation with rutin reduced body weight and adipose tissue mass, despite equivalent energy intake (p < 0.05). Rutin significantly increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as gene expression related to mitochondrial biogenesis, such as peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1α), nuclear respiratory factor-1 (NRF-1), transcription factor A (Tfam), and nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, sirtulin1 (SIRT1) in skeletal muscle (p < 0.05). Moreover, rutin consumption increased muscle adenosine monophosphate-activated protein kinase (AMPK) activity by 40% (p < 0.05). Taken together, these results suggested at least partial involvement of muscle mitochondria and AMPK activation in the rutin-mediated beneficial effect on obesity. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
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