A Standardized Extract of Rhus verniciflua Stokes Protects Wistar Rats Against Lipopolysaccharide-Induced Acute Inflammation
- 주제(키워드) Fustin , Inflammation , Lipopolysaccharide , Rhus verniciflua stokes extract
- 발행기관 Mary Ann Liebert Inc.
- 발행년도 2015
- URI http://www.dcollection.net/handler/ewha/000000120196
- 본문언어 영어
- Published As http://dx.doi.org/10.1089/jmf.2014.3411
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Rhus verniciflua stokes (RVS) (Anacardiaceae) has been traditionally used as a folk remedy for gastritis, several cancers, and various metabolic diseases. The present study evaluated the anti-inflammatory effect of RVS extract standardized to fustin content using lipopolysaccharide (LPS)-stimulated rats. The rats were randomly divided into six groups and intragastrically administered 0, 100, 250, or 500mg/kg body weight (bw) of RVS or 15mg/kg bw of fustin for 14 days. LPS was intraperitoneally injected 18h before sacrifice. The nitric oxide levels of RVS extract in either the serum or liver were significantly decreased compared to the LPS-treated rats (P<.05). The treatment with the RVS extract also blunted the rise of malondialdehyde levels in the liver (P<.05). The administration of RVS extract and fustin significantly prevented the elevation of interleukin 6 cytokine, iNOS, and COX-2 mRNA expression in the liver. Inflammatory cell infiltration was also significantly attenuated by the RVS extract or fustin supplementation. These results suggest that our standardized RVS extract has preventive effects on inflammatory reactions. © Copyright 2015, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2015.
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