Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases
- 등재 SCIE, SCOPUS
- 발행기관 Hindawi Publishing Corporation
- 발행년도 2015
- URI http://www.dcollection.net/handler/ewha/000000120236
- 본문언어 영어
- Published As http://dx.doi.org/10.1155/2015/276850
초록/요약
Most chronic liver diseases (CLDs) are characterized by inflammatory processes with aberrant expressions of various pro-and anti-inflammatory mediators in the liver. These mediators are the driving force of many inflammatory liver disorders, which often result in fibrosis, cirrhosis, and liver tumorigenesis. c-Myc is involved in many cellular events such as cell growth, proliferation, and differentiation. c-Myc upregulates IL-8, IL-10, TNF-α, and TGF-β, while IL-1, IL-2, IL-4, TNF-α, and TGF-β promote c-Myc expression. Their interactions play a central role in fibrosis, cirrhosis, and liver cancer. Molecular interference of their interactions offers possible therapeutic potential for CLDs. In this review, current knowledge of the molecular interactions between c-Myc and various well known inflammatory mediators is discussed. © 2015 Ting Liu et al.
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