Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis
- 등재 SCIE, SCOPUS
- 발행기관 American Chemical Society
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000120606
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acs.jnatprod.5b00746
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Chemical investigation of a marine-derived actinomycete isolated from marine sediments collected off the coast of southern California and identified as a Nocardiopsis sp. (strain CNQ115) led to the isolation of two new 4-aminoimidazole alkaloids, nocarimidazoles A (1) and B (2). The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Nocarimidazoles A and B possess a 4-aminoimidazole ring combined with a conjugated carbonyl side chain, which is rarely found in microbial secondary metabolites. © 2015 The American Chemical Society and American Society of Pharmacognosy.
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