Identification of new pyrrole alkaloids from the fruits of Lycium chinense
- 주제(키워드) Absolute configuration , ECD , Lycium chinense , Pyrrole alkaloid , Solanaceae
- 등재 SCIE, KCI등재, SCOPUS
- 발행기관 Pharmaceutical Society of Korea
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000122668
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12272-015-0695-3
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Three new minor pyrrole alkaloids, 3-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]pentanedioic acid (1), (2R)-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-1-methoxy-1-oxobutanoic acid (2), and methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-4-methylpentanoate (3) were isolated from the fruits of Lycium chinense Miller (Solanaceae), along with the known compound, methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-3-(phenyl)propanoate (4). The structures of 1–4 were elucidated by analysis of their 1D- and 2D-NMR and HRMS data. The absolute configurations of 2–4, possessing a stereogenic center in each structure, were determined by comparison of their experimental electronic circular dichroism (ECD) with those of calculated ECD values. © 2015 The Pharmaceutical Society of Korea
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