Change of health-related profiles after Imatinib cessation in chronic phase chronic myeloid leukemia patients
- 주제(키워드) Chronic myeloid leukemia , imatinib cessation , quality-of-life
- 등재 SCIE, SCOPUS
- 발행기관 Taylor and Francis Ltd
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000123368
- 본문언어 영어
- Published As http://dx.doi.org/10.3109/10428194.2015.1049166
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
The aim of this study was to investigate the changes in health-related profiles including quality-of-life (HRQoL) in the chronic myeloid leukemia (CML) patients who discontinued imatinib (IM). An HRQoL survey composed of 43 parameters about IM-related adverse events (AEs), physical health-related and mental health-related was provided at baseline and 6 months post-discontinuation. A total of 55 patients with a sustained UMRD over 6 months were analyzed. Although the majority of IM-related AEs were significantly improved, unexpectedly pruritus and musculoskeletal pain worsen or newly develop in 29.1% and 21.8% of patients, respectively. The improvements in physical and mental health condition were variable in individual patients. In addition, rapid restorations of the hematological and biochemical parameters were observed. The results showed the changes of HRQoL and laboratory tests in treatment-off patients and the necessity of continuing physical and mental support for some patients in tyrosine kinase inhibitor (TKI)-off studies. © 2015 Informa UK, Ltd.
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