High hydrostatic pressure extract of red ginseng attenuates inflammation in rats with high-fat diet induced obesity
- 주제(키워드) Gene expression , High hydrostatic pressure , High-fat diet , Inflammation , Red ginseng
- 등재 KCI등재, SCOPUS
- 발행기관 Korean Society of Food Science and Nutrition
- 발행년도 2015
- URI http://www.dcollection.net/handler/ewha/000000123370
- 본문언어 영어
- Published As http://dx.doi.org/10.3746/pnf.2015.20.4.253
초록/요약
Chronic low-grade inflammation is associated with obesity. This study investigated effect of high hydrostatic pressure extract of red ginseng (HRG) on inflammation in rats with high-fat (HF) diet induced obesity. Male, Sprague-Dawley rats (80∼110 g) were randomly divided into two groups, and fed a 45% HF diet (HF) and a 45% HF diet containing 1.5% HRG (HF+HRG) for 14 weeks. At the end of the experiment, the serum leptin level was reduced by the HRG supplementation. The mRNA expression of genes related to adipogenesis including peroxisome proliferator-activated receptorgamma and adipocyte protein 2 was down-regulated in the white adipose tissue (WAT). The mRNA levels of major inflammatory cytokines such as tumor necrosis factor-α, monocyte chemoattractant protein 1, and interleukin-6 were remarkably down-regulated by the HRG in WAT. These results suggest that HRG might be beneficial in ameliorating the inflammation-associated health complications by suppressing adipogenic and pro-inflammatory gene expression. Copyright © 2015 by The Korean Society of Food Science and Nutrition. All rights Reserved.
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