β-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells
- 주제(키워드) Breast cancer , Cyclin D1 , Estrogen receptor , Ubiquitination , β-thujaplicin
- 등재 SCIE, SCOPUS
- 발행기관 Japan Society for Bioscience Biotechnology and Agrochemistry
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000131033
- 본문언어 영어
- Published As http://dx.doi.org/10.1080/09168451.2015.1008978
초록/요약
β-Thujaplicin, one of the major constituents in Chamaecyparis obtusa, has been demonstrated to exert different health beneficial efficacy, but the role of β-thujaplicin in regulating mammary tumorigene-sis has not been investigated. In this study, we found that β-thujaplicin significantly suppressed the proliferation through arresting the cell cycle transition from G1 to S phase as well as inhibited the expression of cell cycle-related proteins, cyclin D1, and cyclin-dependent kinase 4 (CDK4) in MCF-7 and T47D luminal subtype breast cancer cells. In addition, estrogen receptor α (ER-α) was down-regulated by β-thujaplicin via enhanced proteolysis by ubiqui-tination, which led to cell growth inhibition. These results suggest that β-thujaplicin may be considered as a potent agent regulating the hormone sensitive mammary tumorigenesis. © 2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
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