Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy
- 주제(키워드) 5-Fluorouracil , Colorectal neoplasma , Hyperammonemia , Metabolic brain diseases
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 Korean Surgical Society
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000134608
- 본문언어 영어
- Published As http://dx.doi.org/10.4174/astr.2016.90.3.179
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy. Copyright © 2016, the Korean Surgical Society.
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