Is the presence of IgG4+ cells within urothelial carcinomas of the renal pelvis that contain rhabdoid and sarcomatoid features associated with IgG4-related diseases?
- 주제(키워드) IgG4 , Plasma cell , Rhabdoid , Urothelial carcinoma
- 등재 SCIE, SCOPUS
- 발행기관 E-Century Publishing Corporation
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000134753
- 본문언어 영어
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
A 69-year-old male underwent nephrectomy after presenting with a renal mass, as visualized through imaging. Histologic evaluation of the specimen revealed a papillary urothelial carcinoma (UC) in the renal pelvis with infiltration into the renal parenchyma that showed sarcomatoid and rhabdoid features; these features are typically associated with mixed inflammatory infiltrate, storiform fibrosis, and obliterative phlebitis, which is reminiscent of IgG4-related disease (IgG4-RD). Immunohistochemical labeling for IgG4 plasma cells showed that there were >50 cells in a single high-power field and the ratio of IgG4/IgG was >40%; these results are consistent with a diagnosis of IgG4-RD. Herein, we describe the first case of UC that has both sarcomatoid and rhabdoid features and high proportions of IgG4+ plasma cells.
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