Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity
- 등재 SCIE, SCOPUS
- 발행기관 American Chemical Society
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000136232
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acs.jnatprod.6b00004
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
A new inhibitor, acredinone C (1), of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation was isolated from the culture broth of the fungus Acremonium sp. (F9A015) along with acredinones A (2) and B (3). The structure of acredinone C (1), which incorporates benzophenone and xanthone moieties, was established by the analyses of combined spectroscopic data including 1D and 2D NMR and MS. All of the acredinones studied efficiently inhibited the RANKL-induced formation of TRAP+-MNCs in a dose-dependent manner without any cytotoxicity up to 10 μM. Acredinone A showed dual activity in both osteoclast and osteoblast differentiation in vitro and good efficacy in an animal disease model of bone formation. © 2016 The American Chemical Society and American Society of Pharmacognosy.
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