Effects of neodymium–yttrium–aluminum garnet (Nd: YAG) pulsed high-intensity laser therapy on full thickness wound healing in an experimental animal model
- 주제(키워드) Granulation tissue , laser therapy , wound healing
- 등재 SCIE, SCOPUS
- 발행기관 Taylor and Francis Ltd
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000139606
- 본문언어 영어
- Published As http://dx.doi.org/10.1080/14764172.2016.1202421
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Objective: Wound healing can be aided by the use of low- and medium-intensity lasers. The use of pulsed neodymium-doped yttrium aluminum garnet (Nd:YAG) high-intensity laser therapy (HILT) with a 1064-nm wavelength laser provides deeper and more efficient penetration into tissue as it is being less absorbed by chromophores in tissue, e.g., hemoglobin, melanin, and water, thereby enhancing the wound-healing process. In this study, we examined the effect of HILT on wound healing with a Q-switched pulsed Nd:YAG laser in an animal model. Design: Sixty SKH1 hairless male mice (seven weeks old) were randomly divided into four groups according to the amount of laser fluence: control, group 1 (0.8 J/cm2), group 2 (1.6 J/cm2), and group 3 (2.0 J/cm2). Laser treatment was provided to groups 1, 2, and 3 with a 1064-nm Q-switched Nd:YAG laser. Histological analysis was performed with hematoxylin and eosin staining, Masson's Trichrome staining, and Ki-67 staining. Results: Statistically significant increases in the accumulation of collagen fibers, thickness of granulation tissue, and numbers of fibroblasts were observed in group 2 (treated with 1.6 J/cm2) as compared with the control (no laser treatment), group 1 (treated with 0.8 J/cm2), and group 3 (treated with 2.0 J/cm2). Conclusion: Nd:YAG HILT stimulated fibroblast proliferation and increased extracellular matrix production. We expect that this therapy could accelerate the wound-healing process. © 2016 Taylor & Francis Group, LLC
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