Cellular internalization and morphological analysis after intravenous injection of a highly hydrophilic octahedral rhenium cluster complex - a new promising X-ray contrast agent
- 주제(키워드) Acute intravenous toxicity , Cellular internalization , Drug development , Octahedral rhenium cluster complex , Safety assessment , Vascular contrast agent
- 등재 SCIE, SCOPUS
- 발행기관 John Wiley and Sons Ltd
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000139631
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/cmmi.1707
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
The octahedral cluster compound Na2H8[(Re6Se8)(P(C2H4CONH2)(C2H4COO)2)6] has been shown to be highly radio dense, thus becoming a promising X-ray contrast agent. It was also shown that this compound had low cytotoxic effect in vitro, low acute toxicity in vivo and was eliminated rapidly from the body through the urinary tract. The present contribution describes a more detailed cellular internalization assay and morphological analysis after intravenous injection of this hexarhenium cluster compound at different doses. The median lethal dose (LD50) of intravenously administrated compound was calculated (4.67±0.69g/kg). Results of the study clearly indicated that the cluster complex Hn[(Re6Se8)(P(C2H4CONH2)(C2H4COO)2)6]n-10 was not internalized into cells in vitro and induced only moderate morphological alterations of kidneys at high doses without any changes in morphology of liver, spleen, duodenum, or heart of mice. © 2016 John Wiley & Sons, Ltd.
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