The Roles of CD137 Signaling in Atherosclerosis
- 주제(키워드) CD137 , Atherosclerosis , T cell , Plaque stability
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SOC CARDIOLOGY
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000139856
- 본문언어 영어
- Published As http://dx.doi.org/10.4070/kcj.2016.46.6.753
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
The tumor necrosis factor receptor superfamily (TNFRSF), which includes CD40, LIGHT, and OX40, plays important roles in the initiation and progression of cardiovascular diseases, involving atherosclerosis. CD137, a member of TNFRSF, is a well-known activation-induced T cell co-stimulatory molecule and has been reported to be expressed in human atherosclerotic plaque lesions, and plays pivotal roles in mediating disease processes. In this review, we focus on and summarize recent advances in mouse studies on the involvement of CD137 signaling in the pathogenesis and plaque stability of atherosclerosis, thereby highlighting a valuable therapeutic target in atherosclerosis.
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