Aluminium ion-promoted radical-scavenging reaction of methylated hydroquinone derivatives
- 등재 SCIE, SCOPUS
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000140047
- 본문언어 영어
- Published As http://dx.doi.org/10.1039/c6ob01470d
초록/요약
The effect of the aluminium ion (Al3+) on the scavenging reaction of a 2,2-diphenyl-1-picrylhydrazyl radical (DPPH center dot), as a reactivity model of reactive oxygen species, with hydroquinone (QH(2)) and its methylated derivatives (Me(n)QH(2), n = 1-4) was investigated using stopped-flow and electrochemical techniques in a hydroalcoholic medium. The second-order rate constants (k) for the DPPH center dot-scavenging reaction of the hydroquinones increased with the increasing number of methyl substituents. Upon addition of Al3+, the k values significantly increased depending on the concentration of Al3+. Such an accelerating effect of Al3+ on the DPPH center dot-scavenging rates of the hydroquinones results from the remarkable positive shift of the one-electron reduction potential (E-red) of DPPH center dot in the presence of Al3+. These results demonstrate that Al3+, a strong Lewis acid, can act as a radical-scavenging promoter by stabilising the one-electron reduced species of the radical, although Al3+ is reported not only to act as a pro-oxidant but also to strongly interact with biomolecules, showing toxicities.
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