Anti-adipogenic and anti- diabetic effects of cis-3 ',4 '-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro
- 주제(키워드) Adipocytes , Adipogenesis , Anti-diabetes , Anti-obesity , Peucedanum japonicum Thunb leaves
- 등재 SCIE, SCOPUS
- 발행기관 PERGAMON-ELSEVIER SCIENCE LTD
- 발행년도 2016
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000140088
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.bmcl.2016.08.056
초록/요약
Peucedanum japonicum Thunb is a medicinal plant belonging to the family Umbelliferae. This study evaluated the anti-diabetic and anti-obesity effects of cis-3',4'-diisovalerylkhellactone (cDIVK) isolated from Peucedanum japonicum Thunb leaves. cDIVK (3' and 5' mu M) effectively inhibited adipocyte differentiation and fat accumulation, whereas it stimulated glucose uptake compared with the control in 3T3-L1 cells. cDIVK significantly increased AMPK activation and suppressed protein and mRNA expression of major adipogenic transcriptional factors such as C/EBP alpha, PPAR gamma and SREBP-1c in 3T3-L1 cells. In addition, cDIVK had potential alpha-glucosidase inhibitory activity. These results indicated that cDIVK may act as a natural dual therapeutic agent for diabetes and obesity. (C) 2016 Elsevier Ltd. All rights reserved.
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