An aniline bearing hemicyanine derivative serves as a mitochondria selective probe
- 주제(키워드) Fluorescent probe , Fluorescent sensor , Mitochondria selective probe , Mitochondria staining probe
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier Ltd
- 발행년도 2017
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000141688
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.dyepig.2016.09.010
초록/요약
Mitochondria play key roles in a variety of pathologies, such as Alzheimer's disease and cancer. Because of this, the development of mitochondria staining probes has attracted great attention. In the current study, we designed, prepared and explored the properties of the hemicyanine derivative, HCA-Mito, bearing an aniline moiety. The results show that this substance serves as a mitochondria staining probe. HCA-Mito, which is insensitive to pH and has a low cytotoxicity, shows a high coincidence with the mitochondria specific dyes, MitoTracker Red and MitoTracker Deep Red. More importantly, the fibrous network structure of mitochondria is clearly stained by using HCA-Mito. © 2016 Elsevier Ltd
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