Cadiolides J–M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja
- 주제(키워드) Antibacterial activity , Pseudodistoma antinboja , Tunicate
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier Ltd
- 발행년도 2017
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000141825
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.bmcl.2016.12.016
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid. © 2016 Elsevier Ltd
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