The role of macrophage lipophagy in reverse cholesterol transport
- 주제(키워드) Atherosclerosis , Cholesterol efflux , Lipophagy , Macrophages , Reverse cholesterol transport
- 등재 SCOPUS, KCI등재
- 발행기관 Korean Endocrine Society
- 발행년도 2017
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000145499
- 본문언어 영어
- Published As http://dx.doi.org/10.3803/EnM.2017.32.1.41
초록/요약
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis. © 2017 Korean Endocrine Society.
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