GMP and IMP are competitive inhibitors of CMY-10, an extended-spectrum class C β-lactamase
- 주제(키워드) Competitive inhibitor , GMP , IMP , β-lactamases
- 등재 SCIE, SCOPUS
- 발행기관 American Society for Microbiology
- 발행년도 2017
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000145608
- 본문언어 영어
- Published As http://dx.doi.org/10.1128/AAC.00098-17
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Nucleotides were effective in inhibiting the class C β-lactamase CMY-10. IMP was the most potent competitive inhibitor, with a Ki value of 16.2 μM. The crystal structure of CMY-10 complexed with GMP or IMP revealed that nucleotides fit into the R2 subsite of the active site with a unique vertical binding mode where the phosphate group at one terminus is deeply bound in the subsite and the base at the other terminus faces the solvent. Copyright © 2017 American Society for Microbiology. All Rights Reserved.
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