miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation
- 주제(키워드) acute , CD8 , differentiation , Foxo1 , infection , LCMV , memory , miR-150 , primary immune response , recall
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier B.V.
- 발행년도 2017
- URI http://www.dcollection.net/handler/ewha/000000146926
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.celrep.2017.08.065
초록/요약
MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8+ T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8+ T cells. After acute virus infection, miR-150 knockout (KO) mice exhibited an accelerated differentiation of CD8+ T cells into memory cells and improved production of effector cytokines. Additionally, miR-150 KO CD8+ T cells displayed an enhanced recall response and improved protection against infections with another virus and bacteria. We found that forkhead box O1 (Foxo1) and T cell-specific transcription factor 1 (TCF1) are upregulated during the early activation phase in miR-150 KO CD8+ T cells and that miR-150 directly targets and suppresses Foxo1. These results suggest that miR-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation, which might aid in the development of improved vaccines and T cell therapeutics. © 2017 The Authors
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