Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5 years of age: The Mothers and Children's Environmental Health (MOCEH) study
- 주제(키워드) Autistic behavior , Birth cohort , Blood mercury , Early childhood exposure , Prenatal exposure
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier B.V.
- 발행년도 2017
- URI http://www.dcollection.net/handler/ewha/000000147017
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.scitotenv.2017.06.227
초록/요약
Background Although mercury is an established neurotoxin, only few longitudinal studies have investigated the association between prenatal and early childhood mercury exposure and autistic behaviors. Methods We conducted a longitudinal cohort study using an ongoing prospective birth cohort initiated in 2006, wherein blood mercury levels were measured at early and late pregnancy; in cord blood; and at 2 and 3 years of age. We analyzed 458 mother-child pairs. Autistic behaviors were assessed using the Social Responsiveness Scale (SRS) at 5 years of age. Both continuous SRS T-scores and T-scores dichotomized by a score of ≥ 60 or < 60 were used as outcomes. Results The geometric mean of mercury concentrations in cord blood was 5.52 μg/L. In adjusted models, a doubling of blood mercury levels at late pregnancy (β = 1.84, 95% confidence interval [CI]: 0.39, 3.29), in cord blood (β = 2.24, 95% CI: 0.22, 4.27), and at 2 years (β = 2.12, 95% CI: 0.54, 3.70) and 3 years (β = 2.80, 95% CI: 0.89, 4.72) of age was positively associated with the SRS T-scores. When the SRS T-scores were dichotomized, we observed positive associations with mercury levels at late pregnancy (relative risk [RR] = 1.31, 95% CI: 1.08, 1.60) and in cord blood (RR = 1.28, 95% CI: 1.01, 1.63). Conclusion We found that blood mercury levels at late pregnancy and early childhood were associated with more autistic behaviors in children at 5 years of age. Further study on the long-term effects of mercury exposure is recommended. © 2016 Elsevier B.V.
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