2-Chlorophenyl-substituted benzofuro[3,2-b] pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent
- 주제(키워드) Heterocycles , Benzofuro[3 , 2-b] pyridines , Chlorine-substituent , Topoisomerase I and II inhibition , Antiproliferative activity
- 등재 SCIE, SCOPUS
- 발행기관 PERGAMON-ELSEVIER SCIENCE LTD
- 발행년도 2017
- URI http://www.dcollection.net/handler/ewha/000000147075
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.bmcl.2017.06.025
초록/요약
A new series of 2-chloropheny-substituted benzofuro[3,2-b] pyridines were designed, synthesized, and evaluated for topoisomerase I and II inhibition and antiproliferative activity. Compounds 17-19, 23, 24, 26, and 27 exhibited excellent topo II inhibitory activity. A systematic structure-activity relationship study revealed the important role of chlorine substitution in the strong topoisomerase inhibitory activity. (C) 2017 Elsevier Ltd. All rights reserved.
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