Molecular Neuroimaging in Posttraumatic Stress Disorder
- 주제(키워드) Posttraumatic stress disorder (PTSD) , Molecular neuroimaging , Positron emission tomography (PET) , Single photon emission computed tomography (SPECT) , Magnetic resonance spectroscopy (MRS)
- 관리정보기술 faculty
- 등재 KCI등재
- 발행기관 KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
- 발행년도 2016
- URI http://www.dcollection.net/handler/ewha/000000147185
- 본문언어 영어
- Published As http://dx.doi.org/10.5607/en.2016.25.6.277
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Over the past decade, an increasing number of neuroimaging studies have provided insight into the neurobiological mechanisms of posttraumatic stress disorder (PSTD). In particular, molecular neuroimaging techniques have been employed in examining metabolic and neurochemical processes in PTSD. This article reviews molecular neuroimaging studies in PTSD and focuses on findings using three imaging modalities including positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance spectroscopy (MRS). Although there were some inconsistences in the findings, patients with PTSD showed altered cerebral metabolism and perfusion, receptor bindings, and metabolite profiles in the limbic regions, medial prefrontal cortex, and temporal cortex. Studies that have investigated brain correlates of treatment response are also reviewed. Lastly, the limitations of the molecular neuroimaging studies and potential future research directions are discussed.
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