A novel indeno[1,2-b] pyridinone derivative, a DNA intercalative human topoisomerase II alpha catalytic inhibitor, for caspase 3-independent anticancer activity
- 등재 SCIE, SCOPUS
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2017
- URI http://www.dcollection.net/handler/ewha/000000147335
- 본문언어 영어
- Published As http://dx.doi.org/10.1039/c7cc02372c
초록/요약
A novel 2-(furan-2-yl)-4-(pyridin-2-yl)-5H-indeno[1,2-b] pyridin-5-one (TI-1-190) was synthesized using a simple microwave-assisted method and its mode of action was systematically characterized. It is a DNA intercalative human topoisomerase II alpha catalytic inhibitor with much stronger activity and less DNA toxicity than etoposide, a topoisomerase II poison. TI-1-190 displays caspase 3-independent anticancer activity, unlike etoposide.
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