Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy
- 주제(키워드) activatable , nanotheranostics , nucleic-acid-responsive disassembly , photodynamic therapy , supramolecular assembly
- 등재 SCIE, SCOPUS
- 발행기관 American Chemical Society
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000149597
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acsnano.7b07809
초록/요약
Supramolecular chemistry provides a "bottom-up" method to fabricate nanostructures for biomedical applications. Herein, we report a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which not only display nanoscale optical properties but also have the capability of undergoing nucleic-acid-responsive disassembly. These supramolecular assemblies possess activatable fluorescence emission and singlet oxygen generation associated with the formation of free PcS, mild photothermal heating, and a concomitant chemotherapeutic effect associated with the formation of free MA. In vivo evaluations indicate that PcS-MA nanostructures have a high level of accumulation in tumor tissues, are capable of being used for cancer imaging, and have significantly improved anticancer effect compared to that of PcS. This study demonstrates an attractive strategy for overcoming the limitations of photodynamic cancer therapy. © 2017 American Chemical Society.
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