Heat Shock Protein-Inducing Property of Diarylheptanoid Containing Chalcone Moiety from Alpinia katsumadai
- 주제(키워드) Alpinia katsumadai , diarylheptanoid , chalcone , heat shock protein (HSP) , heat shock factor (HSF)
- 주제(기타) Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
- 등재 SCIE, SCOPUS
- 발행기관 MDPI AG
- 발행년도 2017
- URI http://www.dcollection.net/handler/ewha/000000149776
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/molecules22101750
초록/요약
A new diarylheptanoid containing a chalcone moiety, katsumain H (1), was isolated from the seeds of Alpinia katsumadai. The structure was elucidated using a combination of 1D/2D NMR spectroscopy and mass spectrometry data analysis. The absolute configurations of C-3, C-5, and C-7 in 1 were assigned based on its optical rotation and after comparing its NMR chemical shifts with those of its diastereoisomers, katsumain E and katsumain F, which were previously isolated from this plant and characterized. In this study, the stimulatory effects of compounds 1 and 2 were evaluated on heat shock factor 1 (HSF1), heat shock protein 27 (HSP27), and HSP70. Compounds 1 and 2 increased the expression of HSF1 (1.056- and 1.200-fold, respectively), HSP27 (1.312- and 1.242-fold, respectively), and HSP70 (1.234- and 1.271-fold, respectively), without increased cytotoxicity.
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