Vaccination With a Latch Peptide Provides Serotype-Independent Protection Against Group B Streptococcus Infection in Mice
- 주제(키워드) Streptococcus agalactiae , serine , rich repeat , latch , vaccine
- 주제(기타) Immunology; Infectious Diseases; Microbiology
- 등재 SCIE, SCOPUS
- 발행기관 OXFORD UNIV PRESS INC
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000149784
- 본문언어 영어
- Published As http://dx.doi.org/10.1093/infdis/jix565
초록/요약
Streptococcus agalactiae (group B streptococcus [GBS]) is a leading cause of invasive diseases in neonates and severe infections in elderly individuals. GBS serine-rich repeat glycoprotein 1 (Srr1) acts as a critical virulence factor by facilitating GBS invasion into the central nervous system through interaction with the fibrinogen A alpha chain. This study revealed that srr1 is highly conserved, with 86.7% of GBS clinical isolates expressing the protein. Vaccination of mice with different Srr1 truncated peptides revealed that only Srr1 truncates containing the latch domain protected against GBS meningitis. Furthermore, the latch peptide alone was immunogenic and elicited protective antibodies, which efficiently enhanced antibody-mediated opsonophagocytic killing of GBS by HL60 cells and provided heterogeneous protection against 4 different GBS serogroups. Taken together, these findings indicated that the latch domain of Srr1 may constitute an effective peptide vaccine candidate for GBS.
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