Versatile Chemical Derivatizations to Design Glycol Chitosan-Based Drug Carriers
- 주제(키워드) glycol chitosan , chemical derivatizations , nanoparticles , drug carriers , disease therapy
- 주제(기타) Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
- 등재 SCIE, SCOPUS
- 발행기관 MDPI AG
- 발행년도 2017
- URI http://www.dcollection.net/handler/ewha/000000149836
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/molecules22101662
초록/요약
Glycol chitosan (GC) and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules), and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy.
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