Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen
- 등재 SCIE, SCOPUS
- 발행기관 Nature Publishing Group
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000150088
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41467-017-02665-z
초록/요약
Whether hematopoietic cell-restricted distribution of antigens affects the degree of thymic negative selection has not been investigated in detail. Here, we show that T cells specific for hematopoietic cell-restricted antigens (HRA) are not completely deleted in the thymus, using the mouse minor histocompatibility antigen H60, the expression of which is restricted to hematopoietic cells. As a result, low avidity T cells escape from thymic deletion. This incomplete thymic deletion occurs to the T cells developing de novo in the thymus of H60-positive recipients in H60-mismatched bone marrow transplantation (BMT). H60-specific thymic deletion escapee CD8+ T cells exhibit effector differentiation potentials in the periphery and contribute to graft-versus-leukemia effects in the recipients of H60-mismatched BMT, regressing H60+ hematological tumors. These results provide information essential for understanding thymic negative selection and developing a strategy to treat hematological tumors. © 2018 The Author(s).
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