Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations
- 주제(기타) Chemistry, Medicinal
- 설명문(일반) [Choi, Sun] Ewha Womans Univ, Coll Pharm, Natl Leading Res Lab NLRL Mol Modeling & Drug Des, Seoul 03760, South Korea; Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000150091
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acs.jmedchem.6b01453
초록/요약
G protein-coupled receptors (GPCRs) represent the largest and most physiologically important integral membrane protein family, and these receptors respond to a wide variety of physiological and environmental stimuli. GPCRs are among the most critical therapeutic targets for numerous human diseases, and approximately one-third of the currently marketed drugs target this receptor family.The recent breakthroughs in GPCR structural biology have significantly contributed to our understanding of GPCR function, ligand binding, and pharmacological action as well as to the design of new drugs. This perspective highlights the latest advances in GPCR structures with a focus on the receptor ligand interactions of each receptor family in class A nonrhodopsin GPCRs as well as the structural features for their activation, biased :signaling, and allosteric mechanisms. The current state-of-the-art methodologies of structure-based drug design (ODD) approaches in the GPCR research field are also discussed.
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