Development and Validation of Gas Chromatography-Triple Quadrupole Mass Spectrometric Method for Quantitative Determination of Regulated Plasticizers in Medical Infusion Sets
- 주제(기타) Chemistry, Analytical; Engineering, Civil
- 설명문(일반) [Jeon, So Hyeon; Ahn, Yun Gyong] Korea Basic Sci Inst, Western Seoul Ctr, Seoul 03759, South Korea; [Jeon, So Hyeon] Ewha Womans Univ, Dept Environm Sci & Engn, Seoul 03759, South Korea; [Kim, Yong Pyo] Ewha Womans Univ, Dept Chem Engn & Mat Sci, Seoul 03760, South Korea; [Kho, Younglim] Eulji Univ, Dept Hlth Environm & Safety, Seongnam 13135, South Korea; [Shin, Jeoung Hwa] Korea Basic Sci Inst, Seoul Ctr, Seoul 02841, South Korea; [Ji, Won Hyun] Mine Reclamation Corp, Inst Mine Reclamat Technol, Wonju 26464, South Korea
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- 발행기관 HINDAWI LTD
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000150125
- 본문언어 영어
- Published As http://dx.doi.org/10.1155/2018/9470254
초록/요약
A method for the quantitative determination of dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), bis(2-ethylhexyl) adipate (DEHA), bis(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DNOP), dioctyl terephthalate (DOTP), diisononyl phthalate (DINP), and diisodecyl phthalate (DIDP) in medical infusion sets was developed and validated using gas chromatography coupled with triple quadrupole mass spectrometry (GC-MS/MS) in the multiple reaction monitoring (MRM) mode. Solvent extraction with polymer dissolution for sample preparation was employed prior to GC-MS/MS analysis. Average recoveries of the eight target analytes are typically in the range of 91.8-122% with the relative standard deviations of 1.8-17.8%. The limits of quanti A cation (LOQs) of the analytical method were in the ranges of 54.1 to 76.3 ng/g. Analysis using GC-MS/MS provided reliable performance, as well as higher sensitivity and selectivity than GC-MS analysis, especially for the presence of minority plasticizers at different concentrations.
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