Evaluation of Ki-67 index in core needle biopsies and matched breast cancer surgical specimens
- 등재 SCIE, SCOPUS
- 발행기관 College of American Pathologists
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000150136
- 본문언어 영어
- Published As http://dx.doi.org/10.5858/arpa.2017-0014-OA
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Context.-The Ki-67 index is strongly prognostic and is used as a surrogate marker to distinguish luminal A from luminal B breast cancer types. Objective.-To investigate differences in Ki-67 index between core needle biopsy samples and matched surgical samples in breast cancer. Design.-We included patients with invasive breast cancer who did not receive neoadjuvant therapy. A total of 89 pairs of core needle biopsies and surgical specimens were collected, and the Ki-67 index was assessed in hot spot areas using an image analyzer. We applied a 14% Ki-67 index to define low versus high groups. Results.-The Ki-67 index was significantly higher in core needle biopsies than in surgical specimens (P, .001), with a median absolute difference of 3.5%. When we applied 14% as a cutoff, 16 of 89 cases (18%) showed discrepancy. Thirteen cases showed a high Ki-67 index in core needle biopsies but a low Ki-67 index in surgical samples. There were 10 cases (11.2%) that showed discordant luminal A/B types between core needle biopsy and the matched surgical specimen. The reasons for the discordance were poor staining of MIB1 accompanied by fixation issues and intratumoral heterogeneity of the Ki-67 index. Conclusions.-A significant difference in the Ki-67 index between core biopsy and surgical specimens was observed. Our findings indicate that it may be better to perform the Ki-67 assay on the core needle biopsy and the surgical specimen than on only one sample. © Copyright 2018 College of American Pathologists.
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