Benzoxazole derivatives suppress lipopolysaccharide-induced mast cell activation
- 주제(키워드) mast cells , benzoxazole derivatives , 5-lipoxygenase inhibitors , histamine , inflammation
- 주제(기타) Oncology; Medicine, Research & Experimental
- 설명문(일반) [Cho, Kyung-Ah; Park, Minhwa; Kim, Yu-Hee] Ewha Womans Univ, Sch Med, Dept Microbiol, Seoul 07985, South Korea; [Choo, Hea-Young Park] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea; [Choo, Hea-Young Park] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; [Lee, Kyung Ho] Catholic Univ Korea, Coll Med, Bucheon St Marys Hosp, Dept Dermatol, 327 Sosa Ro, Bucheon Si 14647, Gyeonggi Do, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 SPANDIDOS PUBL LTD
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151405
- 본문언어 영어
- Published As http://dx.doi.org/10.3892/mmr.2018.8719
초록/요약
Mast cells are central regulators of allergic inflammation that function by releasing various proallergic inflammatory mediators, including histamine, eicosanoids and proinflammatory cytokines. Occasionally, bacterial infections may initiate or worsen allergic inflammation. A number of studies have indicated that activation of lipoxygenase in mast cells positive regulates allergic inflammatory responses by generating leukotrienes and proinflammatory cytokines. In the present study, the effects of benzoxazole derivatives on the lipopolysaccharide (LPS)-induced expression of proinflammatory cytokines, production of histamine and surface expression of co-stimulatory molecules on bone marrow-derived mast cells (BMMCs) were studied. The benzoxazole derivatives significantly reduced the expression of interleukin (IL)-1 beta, IL-6, IL-13, tumor necrosis factor-alpha, perilipin (PLIN) 2, and PLIN3 in BMMCs treated with LPS. Furthermore, histamine production was suppressed in BMMCs treated with LPS, or treated with phorbol-12-myristate-13-acetate/ionomycin. Benzoxazole derivatives marginally affected the surface expression of cluster of differentiation (CD)80 and CD86 on BMMCs in the presence of LPS, although LPS alone did not increase the expression of those proteins. Therefore, benzoxazole derivatives inhibited the secretion of proinflammatory cytokines in mast cells and may be potential candidate anti-allergic agents to suppress mast cell activation.
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