Administration of Alpha(s1)-Casein Hydrolysate Increases Sleep and Modulates GABA(A) Receptor Subunit Expression
- 주제(키워드) Sleep , alpha(S1)-CH , Electroencephalogram , GABA(A) receptor
- 주제(기타) Biochemistry & Molecular Biology; Pharmacology & Pharmacy
- 설명문(일반) [Yayeh, Taddesse; Leem, Yea-Hyun; Oh, Seikwan] Ewha Womans Univ, Dept Mol Med, Seoul 07985, South Korea; [Yayeh, Taddesse; Leem, Yea-Hyun; Oh, Seikwan] Ewha Womans Univ, TIDRC, Sch Med, Seoul 07985, South Korea; [Kim, Kyung-Mi; Jung, Jae-Chul] Novarex Co Ltd, Life Sci Res Inst, Ochang 28126, Cheongwon, South Korea; [Schwarz, Jessica] Ingredia SA, 51 Av Lobbedez, F-62033 Arras, France; [Oh, Ki-Wan] Chungbuk Natl Univ, Coll Pharm, Dept Pharm, Cheongju 28160, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SOC APPLIED PHARMACOLOGY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151470
- 본문언어 영어
- Published As http://dx.doi.org/10.4062/biomolther.2017.083
초록/요약
Sleep is the most basic and essential physiological requirement for mental health, and sleep disorders pose potential risks of metabolic and neurodegenerative diseases. Tryptic hydrolysate of alpha(S1)-casein (alpha(S1)-CH) has been shown to possess stress relieving and sleep promoting effects. However, the differential effects of alpha(S1)-CH on electroencephalographic wave patterns and its effects on the protein levels of gamma-aminobutyric acid A (GABA(A)) receptor subtypes in hypothalamic neurons are not well understood. We found alpha(S1)-CH (120, 240 mg/kg) increased sleep duration in mice and reduced sleep-wake cycle numbers in rats. While alpha(S1)-CH (300 mg/kg) increased total sleeping time in rats, it significantly decreased wakefulness. In addition, electroencephalographic theta (theta) power densities were increased whereas alpha (alpha) power densities were decreased by alpha(S1)-CH (300 mg/kg) during sleep-wake cycles. Furthermore, protein expressions of GABA(A) receptor beta(1) subtypes were elevated in rat hypothalamus by alpha(S1)-CH. These results suggest alpha(S1)-CH, through GABA(A) receptor modulation, might be useful for treating sleep disorders.
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