Sleep-Aids Derived from Natural Products
- 주제(키워드) Insomnia , Sleep , Natural products , Pharmacological mechanisms , Electroencephalography (EEG)
- 주제(기타) Biochemistry & Molecular Biology; Pharmacology & Pharmacy
- 설명문(일반) [Hu, Zhenzhen] Nanchang Univ, Dept Pathophysiol, Coll Basic Med, Nanchang 33006, Jiangxi, Peoples R China; [Oh, Seikwan] Ewha Womans Univ, Sch Med, Dept Mol Med, Seoul 07985, South Korea; [Oh, Seikwan] Ewha Womans Univ, Sch Med, TIDRC, Seoul 07985, South Korea; [Ha, Tae-Woo; Hong, Jin-Tae; Oh, Ki-Wan] Chungbuk Natl Univ, Dept Pharm, Coll Pharm, Osong 28160, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SOC APPLIED PHARMACOLOGY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151472
- 본문언어 영어
- Published As http://dx.doi.org/10.4062/biomolther.2018.099
초록/요약
Although drugs such as barbiturates and benzodiazepines are often used for the treatment of insomnia, they are associated with various side effects such as habituations, tolerance and addiction. Alternatively, natural products with minimal unwanted effects have been preferred for the treatment of acute and/or mild insomnia, with additional benefits of overall health-promotion. Basic and clinical researches on the mechanisms of action of natural products have been carried out so far in insomnia treatments. Recent studies have been focusing on diverse chemical components available in natural products, with an interest of developing drugs that can improve sleep duration and quality. In the last 15 years, our co-workers have been actively looking for candidate substances from natural products that can relieve insomnia. This review is, therefore, intended to bring pharmacological data regarding to the effects of natural products on sleep duration and quality, mainly through the activation of GABAA receptors. It is imperative that phytochemicals will provide useful information during electroencephalography (EEG) analysis and serve as an alternative medications for insomnia patients who are reluctant to use conventional drugs.
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