The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia
- 주제(키워드) Chronic myelomonocytic leukemia , WHO classification , Monocytosis
- 주제(기타) Medical Laboratory Technology
- 설명문(일반) [Moon, Yeonsook] Inha Univ, Sch Med, Dept Lab Med, Incheon, South Korea; [Kim, Mi Hyang] Kosin Univ, Coll Med, Dept Lab Med, Busan, South Korea; [Kim, Hye Ryoun] Chung Ang Univ, Coll Med, Dept Lab Med, Seoul, South Korea; [Ahn, Jeong-Yeal] Gachon Univ, Gil Hosp, Dept Lab Med, Incheon, South Korea; [Huh, Jungwon] Ewha Womans Univ, Coll Med, Dept Lab Med, Seoul, South Korea; [Huh, Ji Young] CHA Univ, CHA Bundang Med Ctr, Dept Lab Med, Seongnam, South Korea; [Han, Jae Ho] Ajou Univ, Sch Med, Dept Pathol, Suwon, South Korea; [Park, Joon Seong] Ajou Univ, Sch Med, Dept Hematol Oncol, Suwon, South Korea; [Cho, Sung Ran] Ajou Univ, Sch Med, Dept Lab Med, 164 World Cup Ro, Suwon 16499, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SOC LABORATORY MEDICINE
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151494
- 본문언어 영어
- Published As http://dx.doi.org/10.3343/alm.2018.38.5.481
초록/요약
The 2016 WHO diagnostic criteria for chronic myelomonocytic leukemia (CMML) require both absolute and relative monocytosis (>= 1 x 10(9)/L and >= 10% of white blood cell counts) in peripheral blood. Moreover, myeloproliferative neoplasm (MPN) features in bone marrow and/or MPN-associated mutations tend to support MPN with monocytosis rather than CMML. We assessed the impact of the 2016 WHO criteria on CMML diagnosis, compared with the 2008 WHO criteria, through a retrospective review of the medical records of 38 CMML patients diagnosed according to the 2008 WHO classification. Application of the 2016 WHO criteria resulted in the exclusion of three (8%) patients who did not fulfill the relative monocytosis criterion and eight (21%) patients with an MPN-associated mutation. These 11 patients formed the 2016 WHO others group; the remaining 27 formed the 2016 WHO CMML group. The significant difference in the platelet count and monocyte percentage between the two groups indicated that the 2016 WHO criteria lead to a more homogenous and improved definition of CMML compared with the 2008 WHO criteria, which may have led to over-diagnosis of CMML. More widespread use of molecular tests and more sophisticated clinical and morphological evaluations are necessary to diagnose CMML accurately.
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