Menopausal hormone therapy and the risk of breast cancer by histological type and race: a meta-analysis of randomized controlled trials and cohort studies
- 주제(키워드) Breast cancer , Menopausal hormone therapy , Hormone replacement therapy , Meta-analysis
- 주제(기타) Oncology
- 설명문(일반) [Kim, Sohyun; Ko, Yeonsook; Lee, Hwa Jeong; Lim, Jung-eun] Ewha Womans Univ, Grad Sch Ind Pharmaceut Sci, Seoul, South Korea; [Lee, Hwa Jeong; Lim, Jung-eun] Ewha Womans Univ, Coll Pharm, Seoul, South Korea; [Lim, Jung-eun] Yonsei Univ, Grad Sch Publ Hlth, Inst Hlth Promot, Seoul, South Korea; [Lim, Jung-eun] Yonsei Univ, Grad Sch Publ Hlth, Dept Epidemiol & Hlth Promot, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 SPRINGER
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151512
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s10549-018-4782-2
초록/요약
This meta-analysis investigated the association between the risk of breast cancer and hormone replacement therapy (HRT). Various stratified analyses were performed according to race (Asian/Westerner), HRT type [all hormone therapies, estrogen-only therapy (ET), or combined estrogen-progestin therapy (EPT)], histological breast cancer type (ductal/lobular/mixed ductal-lobular), and estrogen receptor status (ER-positive/ER-negative). A literature search was performed using Pubmed, Embase, and KoreaMed. Twenty-five epidemiological studies including 23 cohort studies and two randomized controlled trials were included in this meta-analysis. Using a random-effects model, HRT use was found to be positively associated with the risk of breast cancer with a pooled hazard ratio (HR) of 1.33 [95% confidence interval (CI) 1.24, 1.44]. Compared with ET, EPT was more strongly associated with breast cancer risk. EPT was associated with both ductal and lobular breast cancer risks [for ductal breast cancer, HR = 1.51 (95% CI 1.28, 1.78); for lobular breast cancer, HR = 1.38 (95% CI 1.20, 1.60)]. According to ER status, all HRTs were associated with the risk of ER-positive breast cancer, but not with that of ER-negative breast cancer. Asian HRT users had a higher risk of breast cancer than western HRT users. Both ET and EPT were significantly associated with the risk of all breast cancer histological types and ER-positive breast cancer.
more