Recent progress on the development of glutathione (GSH) selective fluorescent and colorimetric probes
- 주제(키워드) Fluorescence probes , GSH probes , Colorimetric chemosensors , Biothiol probes , Glutathione probe , Bioimaging
- 주제(기타) Chemistry, Inorganic & Nuclear
- 설명문(일반) [Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Lee, Songyi] Pukyong Natl Univ, Dept Chem, Busan 48513, South Korea; [Li, Jun] Huazhong Agr Univ, Dept Chem, Coll Sci, Wuhan 430070, Peoples R China; [Zhou, Xin] Qingdao Univ, Dept Chem, Qingdao 266071, Peoples R China; [Yin, Jun] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Coll Chem, Minist Educ, Wuhan 430079, Hubei, Peoples R China
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCIENCE SA
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151532
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.ccr.2018.03.021
초록/요약
Glutathione (GSH) plays a key role in many cellular functions. Abnormal levels of GSH is considered to be sign of many diseases. As a result, various fluorescent imaging probes and/or chemosensors for GSH have been developed. Compared to other analytical methods, fluorescence has unique merits, such as excellent detection limits and sensitivity for use in imaging cells, tissues and small animals. However, colorimetric probes undergo distinct color changes, which in most cases can be detected by using the naked eye. This review of studies aimed at the development of GSH probes is presented in a format that is organized by structural features and chemical reactions of the probes. The topics include probes that are based on nanoparticles or nanocomposites, metal ion displacement and coordination and chemical reactions. The reaction based probes are further classified into probes that undergo cleavage of sulphonamide, sulfonate ester and related functional groups, Se-N bond cleavage, aryl substitution reactions, disulfide bond cleavage followed by cyclization, Michael additions, and other processes. (C) 2018 Elsevier B.V. All rights reserved.
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