Factors Associated with Rebleeding in Patients with Peptic Ulcer Bleeding: Analysis of the Korean Peptic Ulcer Bleeding (K-PUB) Study
- 주제(키워드) Peptic ulcer hemorrhage , Rebleeding , Risk factors
- 주제(기타) Gastroenterology & Hepatology
- 설명문(일반) [Kim, Joon Sung; Kim, Byung-Wook; Park, Sung Min] Catholic Univ Korea, Coll Med, Incheon St Marys Hosp, Div Gastroenterol,Dept Internal Med, 56 Dongsu Ro, Incheon 21431, South Korea; [Shim, Ki-Nam] Ewha Womans Univ, Dept Internal Med, Sch Med, Seoul, South Korea; [Jeon, Seong Woo] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; [Kim, Sang-Wook] Chonbuk Natl Univ, Dept Internal Med, Med Sch, Jeonju, South Korea; [Lee, Yong Chan] Yonsei Univ, Severance Hosp, Dept Internal Med, Div Gastroenterol,Coll Med, Seoul, South Korea; [Moon, Hee Seok] Chungnam Natl Univ, Dept Internal Med, Sch Med, Daejeon, South Korea; [Lee, Si Hyung] Yeungnam Univ, Dept Internal Med, Sch Med, Daegu, South Korea; [Jung, Woon Tae] Gyeongsang Natl Univ, Dept Internal Med, Sch Med, Jinju, South Korea; [Kim, Jin Il] Catholic Univ Korea, Yeouido St Marys Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; [Kim, Kyoung Oh] Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea; [Park, Jong-Jae] Korea Univ, Dept Internal Med, Div Gastroenterol, Guro Hosp, Seoul, South Korea; [Chung, Woo Chul] Catholic Univ Korea, St Vincents Hosp, Dept Internal Med, Coll Med, Suwon, South Korea; [Kim, Jeong Hwan] Konkuk Univ, Dept Internal Med, Sch Med, Seoul, South Korea; [Baik, Gwang Ho] Hallym Univ, Dept Internal Med, Coll Med, Chunchon, South Korea; [Oh, Jung Hwan] Catholic Univ Korea, St Paul Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; [Kim, Sun Moon] Konyang Univ Hosp, Dept Internal Med, Daejeon, South Korea; [Kim, Hyun Soo] Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea; [Yang, Chang Heon] Dongguk Univ, Dept Internal Med, Coll Med, Gyeongju, South Korea; [Jung, Jin Tae] Daegu Catholic Univ, Dept Internal Med, Div Gastroenterol, Coll Med, Daegu, South Korea; [Lim, Chul Hyun] Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; [Song, Hyun Joo] Jeju Natl Univ, Dept Internal Med, Sch Med, Jeju, South Korea; [Kim, Yong Sik] Eulji Univ, Dept Internal Med, Coll Med, Daejeon, South Korea; [Ha Kim, Gwang] Pusan Natl Univ, Dept Internal Med, Sch Med, Busan, South Korea; [Kim, Jie-Hyun] Yonsei Univ, Dept Internal Med, Gangnam Severance Hosp, Coll Med, Seoul, South Korea; [Chung, Jae-Il] Sahmyook Med Ctr, Dept Internal Med, Seoul, South Korea; [Lee, Jun Haeng] Sungkyunkwan Univ, Sch Med, Dept Med, Samsung Med Ctr, Seoul, South Korea; [Choi, Min Ho] Hallym Univ, Coll Med, Dongtan Sacred Heart Hosp, Dept Internal Med, Hwaseong, South Korea; [Choi, Jong-Kyoung] Natl Med Ctr, Dept Internal Med, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 EDITORIAL OFFICE GUT & LIVER
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151536
- 본문언어 영어
- Published As http://dx.doi.org/10.5009/gnl17138
초록/요약
Background/Aims: Rebleeding is associated with mortality in patients with peptic ulcer bleeding (PUB), and risk stratification is important for the management of these patients. The purpose of our study was to examine the risk factors associated with rebleeding in patients with PUB. Methods: The Korean Peptic Ulcer Bleeding registry is a large prospectively collected database of patients with PUB who were hospitalized between 2014 and 2015 at 28 medical centers in Korea. We examined the basic characteristics and clinical outcomes of patients in this registry. Univariate and multivariate analyses were performed to identify the factors associated with rebleeding. Results: In total, 904 patients with PUB were registered, and 897 patients were analyzed. Rebleeding occurred in 7.1% of the patients (64), and the 30-day mortality was 1.0% (nine patients). According to the multivariate analysis, the risk factors for rebleeding were the presence of co-morbidities, use of multiple drugs, albumin levels, and hematemesis/hematochezia as initial presentations. Conclusions: The presence of co-morbidities, use of multiple drugs, albumin levels, and initial presentations with hematemesis/hematochezia can be indicators of rebleeding in patients with PUB. The wide use of proton pump inhibitors and prompt endoscopic interventions may explain the low incidence of rebleeding and low mortality rates in Korea.
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