Preoperative medication use and its association with postoperative length of hospital stay in surgical oncology patients receiving comprehensive geriatric assessment
- 주제(키워드) comprehensive geriatric assessment , postoperative length of stay , preoperative medication , surgical oncology patients
- 주제(기타) Geriatrics & Gerontology; Gerontology
- 설명문(일반) [Jeong, Young Mi; Lee, Eun Sook] Seoul Natl Univ, Dept Pharm, Bundang Hosp, Seongnam, South Korea; [Kim, Kwang Ill] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; [Jeong, Young Mi; Lee, Byung Koo; Gwak, Hye Sun] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea; [Jeong, Young Mi; Lee, Byung Koo; Gwak, Hye Sun] Ewha Womans Univ, Div Life Pharmaceut Sci, Seoul, South Korea; [Lee, Kyung Eun] Chungbuk Natl Univ, Coll Pharm, Cheongju, South Korea; [Chung, Jee Eun] Sungkyunkwan Univ, Coll Pharm, Suwon, South Korea
- 등재 SCIE, SSCI
- 발행기관 WILEY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151584
- 본문언어 영어
- Published As http://dx.doi.org/10.1111/ggi.13127
초록/요약
Aim: The present study aimed to investigate whether preoperative medication use is associated with postoperative length of hospital stay in older adults undergoing cancer surgery. Methods: Patients aged >= 65 years who were scheduled for cancer surgery and presented for preoperative comprehensive geriatric assessment were included in the present study. Cognitive function evaluation and preoperative medication review were carried out, as well as baseline characteristics of participants collected from electronic medical records. The primary efficacy variable was the postoperative length of stay (LOS) in hospital. Results: A total of 475 cancer patients were included for the analysis. Baseline characteristics of participants including older age, lower body mass index (BMI) and male sex were associated with longer postoperative stay. Among the clinical variables, cancer type, number of medications, potentially inappropriatemedication (PIM) and delirium-inducing medication were found as statistically significant factors for postoperative LOS. In multivariate analysis, variables independently associated with postoperative LOS were cancer type, PIM use, BMI, and the number of medications after controlling for age, BMI, sex, cancer type, the number of medications, PIM, and delirium-inducing medication. In subgroup analysis of gastrointestinal cancer, multiple linear regression analysis showed that PIM use and BMI were significantly associated with LOS after adjustment for age, sex, and number of medication. Conclusions: The present study supports the impact of medication use on postoperative LOS in geriatric oncology patients. The results add a further aspect to medication optimization in older patients undergoing cancer surgery.
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