Age-Specific Cutoff Scores on a T1-Weighted Axial Medial Temporal-Lobe Atrophy Visual Rating Scale in Alzheimer's Disease Using Clinical Research Center for Dementia of South Korea Data
- 주제(키워드) medial temporal-lobe atrophy , T1-weighted axial Visual Rating Scale , cutoff score , Alzheimer's disease
- 주제(기타) Clinical Neurology
- 설명문(일반) [Choi, Gyeong Seon; Kim, Geon Ha; Choi, Ji-Hyun; Hwang, Jihye; Kwon, Eunjin; Lee, Seung Ah; Jeong, Jee Hyang] Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea; [Choi, Gyeong Seon] Ewha Womans Univ, Sch Med, Dept Crit Care Med, Seoul, South Korea; [Kong, Kyoung Ae] Ewha Womans Univ, Sch Med, Dept Prevent Med, Seoul, South Korea; [Kang, Hee Jin] Sungkyunkwan Univ, Samsung Changwon Hosp, Sch Med, Dept Neurol, Chang Won, South Korea; [Yoon, Bora] Konyang Univ, Coll Med, Konyang Univ Hosp, Dept Neurol, Daejeon, South Korea; [Kim, Byeong C.] Chonnam Natl Univ, Med Sch, Dept Neurol, Gwangju, South Korea; [Yang, Dong Won] Catholic Univ Korea, Coll Med, Dept Neurol, Seoul, South Korea; [Na, Duk L.] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul, South Korea; [Kim, Eun-Joo] Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Dept Neurol, Busan, South Korea; [Kim, Eun-Joo; Lee, Kang Youn] Med Res Inst, Busan, South Korea; [Na, Hae Ri] Bobath Mem Hosp, Brain Fitness Ctr, Seongnam, South Korea; [Han, Hyun Jeong] Myongji Hosp, Dept Neurol, Goyang, South Korea; [Lee, Jae-Hong] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul, South Korea; [Kim, Jong Hun] Ilsan Hosp, Dementia Ctr, Dept Neurol, Natl Hlth Insurance Serv, Goyang, South Korea; [Lee, Kang Youn] Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Dept Psychiat, Busan, South Korea; [Park, Kee Hyung] Gachon Univ, Sch Med, Dept Neurol, Incheon, South Korea; [Park, Kyung Won] Dong A Univ, Coll Med, Dept Neurol, Busan, South Korea; [Park, Kyung Won] Inst Convergence Biohlth, Busan, South Korea; [Kim, SangYun] Seoul Natl Univ, Coll Med, Dept Neurol, Seongnam, South Korea; [Kim, SangYun] Seoul Natl Univ, Bundang Hosp, Clin Neurosci Ctr, Seongnam, South Korea; [Han, Seol-Heui] Konkuk Univ, Med Ctr, Dept Neurol, Seoul, South Korea; [Kim, Seong Yoon] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Psychiat, Seoul, South Korea; [Yoon, Soo Jin] Eulji Univ, Coll Med, Dept Neurol, Daejeon, South Korea; [Moon, So Young] Ajou Univ, Sch Med, Dept Neurol, Suwon, South Korea; [Youn, Young Chul] Chung Ang Univ, Coll Med, Dept Neurol, Seoul, South Korea; [Choi, Seong Hye] Inha Univ, Sch Med, Dept Neurol, Incheon, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN NEUROLOGICAL ASSOC
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151593
- 본문언어 영어
- Published As http://dx.doi.org/10.3988/jcn.2018.14.3.275
초록/요약
Background and Purpose Visual assessment of medial temporal-lobe atrophy (MTA) has been quick, reliable, and easy to apply in routine clinical practice. However, one of the limitations in visual assessments of MTA is the lack of widely accepted age-adjusted norms and cutoff scores for MTA for a diagnosis of Alzheimer's disease (AD). This study aimed to determine the optimal cutoff score on a T1-weighted axial MTA Visual Rating Scale (VRS) for differentiating patients with AD from cognitively normal elderly people. Methods The 3,430 recruited subjects comprising 1,427 with no cognitive impairment (NC) and 2003 AD patients were divided into age ranges of 50-59, 60-69, 70-79, and 80-89 years. Of these, 446 participants (218 in the NC group and 228 in the AD group) were chosen by random sampling for inclusion in this study. Each decade age group included 57 individuals, with the exception of 47 subjects being included in the 80- to 89-year NC group. The scores on the T1-weighted axial MTA VRS were graded by two neurologists. The cutoff values were evaluated from the area under the receiver operating characteristic curve. Results The optimal axial MTA VRS cutoff score from discriminating AD from NC increased with age: it was >= as >= 1, >= 2, and >= 3 in subjects aged 50-59, 60-69, 70-79, and 80-89 years, respectively (all p<0.001). Conclusions These results show that the optimal cutoff score on the axial MTA VRS for diagnosing of AD differed according to the decade age group. This information could be of practical usefulness in the clinical setting.
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