Causes of hyperhomocysteinemia and its pathological significance
- 주제(키워드) Homocysteine , Hyperhomocysteinemia , Disease caused by hyperhomocysteinemia
- 주제(기타) Chemistry, Medicinal; Pharmacology & Pharmacy
- 설명문(일반) [Kim, Jihyun; Kim, Hyunhee; Roh, Heewon; Kwon, Youngjoo] Ewha Womans Univ, Ewha Inst Global Pharm Leadership, Coll Pharm, Seoul 120750, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 PHARMACEUTICAL SOC KOREA
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151597
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12272-018-1016-4
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease and a definite risk factor for many other diseases. Homocysteine is biosynthesized from methionine through multiple steps and then goes through one of two major metabolic pathways: remethylation and transsulfuration. Hyperhomocysteinemia is a state in which too much homocysteine is present in the body. The main cause of hyperhomocysteinemia is a dysfunction of enzymes and cofactors associated with the process of homocysteine biosynthesis. Other causes include excessive methionine intake, certain diseases and side effects of some drugs. Hyperhomocysteinemia is a trigger for many diseases, such as atherosclerosis, congestive heart failure, age-related macular degeneration, Alzheimer's disease and hearing loss. There are many studies showing a positive relationship between homocysteine level and various symptoms. We speculate that a high level of homocysteine can be the sole reason or an aggravating factor in numerous diseases for which causal links are not fully understood.
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