Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
- 주제(키워드) <bold>body weight</bold> , <bold>Lactobacillus gasseri</bold> , <bold>obesity</bold> , <bold>probiotics</bold> , <bold>visceral adipose tissue</bold>
- 주제(기타) Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
- 설명문(일반) [Kim, Joohee; Kim, Mi Kyung] Biofood CRO Co Ltd, Seoul, South Korea; [Yun, Jae Moon; Cho, Belong] Seoul Natl Univ Hosp, Dept Family Med, Seoul 03080, South Korea; [Yun, Jae Moon; Cho, Belong] Seoul Natl Univ, Adv Inst Convergence Technol, Suwon, Gyeonggi Do, South Korea; [Yun, Jae Moon; Cho, Belong] Seoul Natl Univ, Inst Aging, Coll Med, Seoul, South Korea; [Kwon, Oran] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul, South Korea
- 발행기관 NEW ROCHELLE
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151652
- ISBN J MED FOOD
- 본문언어 영어
- Published As http://dx.doi.org/10.1089/jmf.2017.3937
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Lactobacillus gasseri BNR17 is a probiotic strain isolated from human breast milk. Animal studies reported that BNR17 inhibited increases in body weight and adipose tissue weights. The purpose of this study was to evaluate the antiobesity effects of BNR17 in humans. In a randomized, double-blind, placebo-controlled trial, 90 volunteers aged 20-75 years with body mass index (BMI) from 25 to 35kg/m(2) were randomized to receive a placebo, low-dose BNR (BNR-L, 10(9) CFU/day), or high-dose BNR (BNR-H, 10(10) CFU/day) for 12 weeks. Body weight, BMI, waist and hip circumferences, waist-to-hip ratio, abdominal adipose tissue areas, body fat mass, lean body mass, and biochemical parameters were assessed at the beginning and end of the trial. Visceral adipose tissue (VAT) was significantly decreased in the BNR-H group compared with the placebo group (P=.038). Difference of VAT areas of the BNR-H group compared with the placebo group after 12-week consumption of BNR17 was significant (-21.6cm(2), P=.012). Waist circumferences were significantly decreased in both the BNR-L and BNL-H groups (P=.045 and .012, respectively) compared with the baseline values, but not in the placebo group. Biochemical parameters were not significantly different among the groups. These findings suggest that daily consumption of BNR17 may contribute to reduced visceral fat mass in obese adults.
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