Phyllodulcin, a natural functional sweetener, improves diabetic metabolic changes by regulating hepatic lipogenesis, inflammation, oxidative stress, fibrosis, and gluconeogenesis in db/db mice
- 주제(키워드) Phyllodulcin , Natural sweetener , Db/db mice , Hepatic lipogenesis , Inflammation , Gluconeogenesis
- 주제(기타) Food Science & Technology
- 설명문(일반) [Kim, Eunju; Kim, Yuri] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 03760, South Korea; [Shin, Jae-Ho; Seok, Pu Reum] Eulji Univ, Dept Biomed Lab Sci, Seongnam Si 13135, Gyunggi Do, South Korea; [Kim, Min-Soo; Yoo, Sang-Ho] Sejong Univ, Dept Food Sci & Biotechnol, 209 Neungdong Ro, Seoul 05006, South Korea; [Kim, Min-Soo; Yoo, Sang-Ho] Sejong Univ, Carbohydrate Bioprod Res Ctr, 209 Neungdong Ro, Seoul 05006, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCIENCE BV
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151708
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.jff.2017.12.038
초록/요약
Phyllodulcin, an isocoumarin derivatives and well-known natural sweetener derived from Hydrangea macro phyla var, was evaluated for its roles in diabetes-related metabolic and genetic changes by regulating glucose homeostasis in the liver. C57BL/KsJ-db/db mice received 20 mg/kg body weight (b.w.) stevioside (SVS 20), 10 mg/kg b.w. phyllodulcin (P 10), or 20 mg/kg b.w. phyllodulcin (P 20) for four weeks. Water and food intake were significantly lower in the phyllodulcin supplemented group compared with the diabetic group. Phyllodulcin supplementation suppressed the levels of fasting blood glucose, HbA1c, and plasma and hepatic triglyceride level. Phyllodulcin improved hepatic lipogenesis, while also suppressing inflammation and oxidative stress. Phyllodulcin inhibited hepatic fibrosis and regulated liver glucose homeostasis. Thus, these results indicate the potential of phyllodulcin to serve as a therapeutic agent to improve global hepatic function and metabolic abnormalities of diabetic conditions and the necessity to be better explored.
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