Xylobiose Prevents High-Fat Diet Induced Mice Obesity by Suppressing Mesenteric Fat Deposition and Metabolic Dysregulation
- 주제(키워드) xylobiose , obesity , adipogenesis , lipogenesis , inflammation , mesenteric adipose tissue
- 주제(기타) Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
- 설명문(일반) [Lim, Soo-min; Kim, Eunju; Kim, Yuri] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 03760, South Korea; [Shin, Jae-Ho; Seok, Pu Reum] Eulji Univ, Dept Biomed Lab Sci, Seongnam Si 13135, Gyunggi Do, South Korea; [Jung, Sangwon] TS Corp, R&D Ctr, Incheon 22300, South Korea; [Yoo, Sang-Ho] Sejong Univ, Dept Food Sci & Biotechnol, 209 Neungdong Ro, Seoul 05006, South Korea; [Yoo, Sang-Ho] Sejong Univ, Carbohydrate Bioprod Res Ctr, 209 Neungdong Ro, Seoul 05006, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151709
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/molecules23030705
초록/요약
Obesity is a public concern and is responsible for various metabolic diseases. Xylobiose (XB), an alternative sweetener, is a major component of xylo-oligosaccharide. The purpose of this study was to investigate the effects of XB on obesity and its associated metabolic changes in related organs. For these studies, mice received a 60% high-fat diet supplemented with 15% D-xylose, 10% XB, or 15% XB as part of the total sucrose content of the diet for ten weeks. Body weight, fat and liver weights, fasting blood glucose, and blood lipids levels were significantly reduced with XB supplementation. Levels of leptin and adipokine were also improved and lipogenic and adipogenic genes in mesenteric fat and liver were down-regulated with XB supplementation. Furthermore, pro-inflammatory cytokines, fatty acid uptake, lipolysis, and beta-oxidation-related gene expression levels in mesenteric fat were down-regulated with XB supplementation. Thus, XB exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabolic disorders.
more