High Dietary Glycemic Load is Associated with Poor Functional Outcome in Patients with Acute Cerebral Infarction
- 주제(키워드) glycemic load , glycemic index , carbohydrate intake , stroke , outcome
- 주제(기타) Clinical Neurology
- 설명문(일반) [Song, Tae-Jin; Chang, Yoonkyung; Chun, Min-Young; Lee, Chan-Young; Kim, Yong-Jae] Ewha Womans Univ, Stroke Ctr, Dept Neurol, Sch Med, 1071 Anyangcheon Ro, Seoul 07985, South Korea; [Kim, A-Ram; Kim, Yuri] Grad Sch Converging Clin & Publ Hlth, Dept Clin Nutr, Seoul, South Korea; [Kim, Yuri] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN NEUROLOGICAL ASSOC
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151710
- 본문언어 영어
- Published As http://dx.doi.org/10.3988/jcn.2018.14.2.165
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Background and Purpose Elevated postprandial blood glucose is a critical risk factor for stroke. The dietary glycemic load (GL) and glycemic index (GI) are frequently used as markers of the postprandial blood glucose response to estimate the overall glycemic effect of diets. We hypothesized that high dietary GL, GI, or total carbohydrate intake is associated with a poor functional outcome in patients with acute ischemic stroke.& para;& para;Methods We prospectively included 263 first-ever ischemic stroke patients who completed a semiquantitative food-frequency questionnaire. The dietary GL, GI, and total carbohydrate intake were investigated by examining the average frequency of intake during the previous year based on reference amounts for various food items. Poor functional outcome was defined as a score on the modified Rankin Scale (mRS) of >= 3 at 3 months after stroke.& para;& para;Results The patients were aged 65.4 +/- 11.7 years (mean +/- standard deviation), and 58.2% of them were male. A multivariate analysis adjusted for age, sex, marital status, prestroke mRS score, diabetes mellitus, hyperlipidemia, body mass index, triglycerides, low-density lipoprotein, hemoglobin A1c, stroke classification, and National Institutes of Health Stroke Scale score, early neurological deterioration, and high-grade white-matter hyperintensities revealed that the dietary GL and total carbohydrate intake were associated with a poor functional outcome, with odds ratios for the top quartile relative to the bottom quartile of 28.93 (95% confidence interval=2.82-296.04) and 36.84 (95% confidence interval=2.99-453.42), respectively (p for trend=0.002 and 0.002, respectively). In contrast, high dietary GI was not associated with a poor functional, outcome (p for trend=0.481).& para;& para;Conclusions Increased dietary GL and carbohydrate intake were associated with a poor shortterm functional outcome after an acute ischemic stroke.
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