A commensal strain of Staphylococcus epidermidis protects against skin neoplasia
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Nakatsuji, Teruaki; Chen, Tiffany H.; Butcher, Anna M.; Shirakawa, Karina T.; Gallo, Richard L.] Univ Calif San Diego, Dept Dermatol, La Jolla, CA 92093 USA; [Trzoss, Lynnie L.; Nam, Sang-Jip; Fenical, William] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA; [Zhou, Wei; Oh, Julia] Jackson Lab Genom Med, Farmington, CT 06032 USA; [Otto, Michael] NIAID, NIH, Bethesda, MD 20892 USA; [Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nano Sci, Global Top Program 5, Seoul, South Korea
- 등재 SCOPUS
- 발행기관 AMER ASSOC ADVANCEMENT SCIENCE
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151782
- 본문언어 영어
- Published As http://dx.doi.org/10.1126/sciadv.aao4502
초록/요약
We report the discovery that strains of Staphylococcus epidermidis produce 6-N-hydroxyaminopurine ( 6-HAP), a molecule that inhibits DNA polymerase activity. In culture, 6-HAP selectively inhibited proliferation of tumor lines but did not inhibit primary keratinocytes. Resistance to 6-HAP was associated with the expression of mitochondrial amidoxime reducing components, enzymes that were not observed in cells sensitive to this compound. Intravenous injection of 6-HAP in mice suppressed the growth of B16F10 melanoma without evidence of systemic toxicity. Colonization of mice with an S. epidermidis strain producing 6-HAP reduced the incidence of ultraviolet-induced tumors compared to mice colonized by a control strain that did not produce 6-HAP. S. epidermidis strains producing 6-HAP were found in the metagenome from multiple healthy human subjects, suggesting that the microbiome of some individuals may confer protection against skin cancer. These findings show a new role for skin commensal bacteria in host defense.
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